Sharp Edge Labs: Discovering Drugs to Treat Genetic Disorders of Protein Trafficking.

Sharp Edge Labs
Sharp Edge LabsTuesday, August 23rd, 2016 at 8:33am
A busy news-day for protein trafficking. This time, trafficking of lysosomes BETWEEN cells to deliver aggregated alpha-Synuclein in Parkinson's, enabling the spread by seeding cells with agregates from other cells. Wow.

https://www.sciencedaily.com/releases/2016/08/160822111818.htm
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Sharp Edge Labs
Sharp Edge LabsTuesday, August 23rd, 2016 at 7:33am
Another twist in protein trafficking biology, illuminated by Stanford scientists.

http://www.scienceandtechnologyresearchnews.com/stanford-scientists-revise-decades-old-model-proteins-move-cells/
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Sharp Edge Labs
Sharp Edge LabsTuesday, August 23rd, 2016 at 6:22am
Huge shout out to fellow Pittsburgh Life Science Company Thar Pharmaceuticals on filing their IPO to take their non-opioid pain medicine into Phase III Trials!
http://www.fiercebiotech.com/biotech/oral-pain-biotech-thar-pharmaceuticals-files-for-50m-public-offering
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Sharp Edge Labs
Sharp Edge LabsFriday, March 25th, 2016 at 10:15am
Sharp Edge Labs announces a drug discovery alliance with stem cell pioneer ORIG3N to bring patients into the earliest stages of the drug discovery process (well, patients' stem cells that is).
http://finance.yahoo.com/news/orig3n-sharp-edge-labs-enter-213800553.html
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Sharp Edge Labs
Sharp Edge Labs shared Alzheimer's Drug Discovery Foundation's post.Thursday, February 11th, 2016 at 10:49am
An important study showing that knowledge is power (power to change).
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Off the Shelf
  • Monogenic Diseases
    Caused by a single gene alteration, monogenic diseases represent an area of high unmet need, but also of great therapeutic opportunity.
  • Trafficking Defects
    Many monogenic diseases result from a mutation that causes improper trafficking, the failure of the mutated protein to get to the right place inside the cell.
  • Patient-Driven Discovery
    Stem-Cell technology allows patients to participate in drug discovery programs at their earliest stages.
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