- We've just added a new post to the "On Our Radar" section of the web-site. This time, we're looking at the role of trafficking of GLUT4 in diabetes, and how trafficking influences insulin sensitivity. Check it out at:
http://www.sharpedgelabs.com/sharp-edge-radar/diabetes-a-trafficking-disorder/ #trafficking, #GLUT4?
- just joined as a scientist in our biology team. Pruthvi brings a wide range of expertise to the group, and we're glad to have him helping us expand our assay portfolio, and providing the best trafficking assay data to our customers. Welcome Pruthvi!?
- The role of trafficking mutations in lysosomal storage disorders. We're working on assays to search for new drugs against these trafficking mutations. See the discussion regarding Gaucher's disease here.
- We're hiring great biologists! At least we will be if we get your resume (or the resume of one of your extraordinary colleagues). We're building the team that creates the industry's leading cellular trafficking assays, and we're starting with biologists with experience in cell-culture, molecular biology and assay development for high throughput screening. Please check out our careers page, and forward along to qualified candidates. We'll be posting additional positions in the coming weeks. Exciting times!?
- We've just released a new PgP(G268V) mutant trafficking assay.
This assay has been used as selectivity assay when developing CFTR trafficking compounds. For example, Vertex's VX-809 clinical candidate increases CFTR trafficking, but does not also increase PgP trafficking. However, an earlier, less selective compound VRT-325 increases surface expression of CFTR and PgP.
The assay is available as a service, and we can also provide you with cells to run the assay in your own lab. Just let us know...